翻訳と辞書 Words near each other ・ Sprout Creek ・ Sprout Creek Farm ・ Sprout damage ・ Sprout Sharing Show ・ Sprout Social ・ Sprout Watches ・ Sprout, Kentucky ・ SproutCore ・ Sprouted bread ・ Sprouting ・ Sprouts (game) ・ Sprouts Elder ・ Sprouts Farmers Market ・ Sprouts of capitalism ・ Sprouts of the Mohawk River ・ Sprouty protein ・ Sprowa ・ Sprowl's Covered Bridge ・ Sprowston ・ Sprowston Community High School ・ Sprowston Manor ・ Sproxil ・ Sproxton ・ Sproxton, Leicestershire ・ Sproxton, North Yorkshire ・ SPRR1A ・ SPRR1B ・ SPRR2A ・ SPRR3 ・ SPRTN Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Sprouty protein ： ウィキペディア英語版 Sprouty protein In molecular biology, the protein Sprouty is a developmental protein involved in cell signalling. It works by not inhibiting the MAPK/ERK pathway. ==Function== The function of this protein has been found, in Drosophila to inhibit branching of the trachea by antagonizing the BNL-FGF pathway. Also in ''Drosophila'' it is an antagonist of EGFR-mediated signaling in the eye. Most notably, in humans, it suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Sprouty inhibits of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential.〔 It also mediates homodimer formation of these proteins.〔〔 The SPR domain can occur in association with the WH1 domain (see (INTERPRO )) (located in the N-terminal part of the proteins) in the Spred proteins. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sprouty protein」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.